Rhein | B2737

Rhein is an anthraquinone derivative that displays diverse biological activities, including anticancer, antioxidant, and anti-inflammatory activities. Also acts as a Fat mass and obesity-associated protein FTO (mRNA N6-methyladenine demethylase) inhibitor (IC50 = 1.2 - 21 μM; Ki = 1.8 μM). Also inhibits ALKBH3 and ALKBH2 (IC50 values are 5.3 and 9.1 μM, respectively). Sensitizes glioblastoma cells to alkylating agents.

Rhein is an anthraquinone derivative that displays diverse biological activities, including anticancer, antioxidant, and anti-inflammatory activities. Also acts as a Fat mass and obesity-associated protein FTO (mRNA N6-methyladenine demethylase) inhibitor (IC50 = 1.2 - 21 μM; Ki = 1.8 μM). Also inhibits ALKBH3 and ALKBH2 (IC50 values are 5.3 and 9.1 μM, respectively). Sensitizes glioblastoma cells to alkylating agents.

B2737 | Rhein DataSheet

Alternate Name/Synonyms: 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid,NSC-38629

Appearance: Yellow solid

Formulation:

CAS Number: 478-43-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₈O₆

Molecular Weight: 284.22

Cell-Permeable?: TRUE

Purity: ≥95%

Solubilities: ~10 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line:

MDL Number:

PubChem CID: 10168

SMILES: C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)C(=O)O

InChi: InChI=1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)

InChi Key: FCDLCPWAQCPTKC-UHFFFAOYSA-N