Ribavirin | 2199

Ribavirin is a nucleoside analog that inhibits the replication of both DNA and RNA viruses, including influenza type A and type B. Ribavirin, as ribavirin 5’-phosphate, affects virus-infected cells primarily by inhibiting the enzyme inosine 5’-monophosphate (IMP) dehydrogenase. It potently suppresses eIF4E-mediated oncogenic transformation of murine cells in vitro, of tumor growth of a mouse model of eIF4E-dependent human squamous cell carcinoma in vivo, and of colony formation of eIF4E-dependent acute myelogenous leukemia cells derived from human patients.

Ribavirin is a nucleoside analog that inhibits the replication of both DNA and RNA viruses, including influenza type A and type B. Ribavirin, as ribavirin 5’-phosphate, affects virus-infected cells primarily by inhibiting the enzyme inosine 5’-monophosphate (IMP) dehydrogenase.

2199 | Ribavirin DataSheet

Alternate Name/Synonyms: 1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide

Appearance: White solid

Formulation: N/A

CAS Number: 36791-04-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₈H₁₂N₄O₅

Molecular Weight: 244.2

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: H2O (100 mM) or DMSO (100 mM)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An antiviral agent

MDL Number: MFCD00058564

PubChem CID: 37542

SMILES: C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N

InChi: InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1

InChi Key: IWUCXVSUMQZMFG-AFCXAGJDSA-N