RIP3 Antibody | 19-657

RIP3 Antibody | 19-657 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human RIP3 (NP_006862.2) .

Research Area: Apoptosis, Cell Cycle, Immunology, Innate Immunity, Signal Transduction

Tested Application: WB, IHC, IF

Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200

Specificiy: N/A

Positive Control 1: Jurkat

Positive Control 2: Mouse spleen

Positive Control 3: Mouse lung

Positive Control 4: Rat lung

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 45-70kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: RIPK3, RIP3, RIP3 beta, RIP3 gamma

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.