RITA | 2469

RITA (reactivation of p53 and induction of tumor cell apoptosis) binds to p53 and induces its accumulation in tumor cells. RITA prevents p53-HDM2 interaction in vitro and in vivo and affects p53 interaction with several negative regulators. It induces expression of p53 target genes and apoptosis in various tumor cell lines expressing wild-type p53.

RITA (reactivation of p53 and induction of tumor cell apoptosis) binds to p53 and induces its accumulation in tumor cells. RITA prevents p53-HDM2 interaction in vitro and in vivo and affects p53 interaction with several negative regulators.

2469 | RITA DataSheet

Alternate Name/Synonyms: 5,5'-(2,5-Furandiyl)bis-2-thiophenem​ethanol; NSC 652287

Appearance: Off-white solid

Formulation: N/A

CAS Number: 213261-59-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₁₂O₃S₂

Molecular Weight: 292.37

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml) or EtOH (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A p53 activator

MDL Number: MFCD03235294

PubChem CID: 374536

SMILES: C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO

InChi: InChI=1S/C14H12O3S2/c15-7-9-1-5-13(18-9)11-3-4-12(17-11)14-6-2-10(8-16)19-14/h1-6,15-16H,7-8H2

InChi Key: KZENBFUSKMWCJF-UHFFFAOYSA-N