Description
RITA (reactivation of p53 and induction of tumor cell apoptosis) binds to p53 and induces its accumulation in tumor cells. RITA prevents p53-HDM2 interaction in vitro and in vivo and affects p53 interaction with several negative regulators. It induces expression of p53 target genes and apoptosis in various tumor cell lines expressing wild-type p53.
RITA (reactivation of p53 and induction of tumor cell apoptosis) binds to p53 and induces its accumulation in tumor cells. RITA prevents p53-HDM2 interaction in vitro and in vivo and affects p53 interaction with several negative regulators.
Alternate Name/Synonyms: 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol; NSC 652287
Appearance: Off-white solid
Formulation: N/A
CAS Number: 213261-59-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₄H₁₂O₃S₂
Molecular Weight: 292.37
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>25 mg/ml) or EtOH (>5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A p53 activator
MDL Number: MFCD03235294
PubChem CID: 374536
SMILES: C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO
InChi: InChI=1S/C14H12O3S2/c15-7-9-1-5-13(18-9)11-3-4-12(17-11)14-6-2-10(8-16)19-14/h1-6,15-16H,7-8H2
InChi Key: KZENBFUSKMWCJF-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |