Ro 31-8220 methanesulfonate | 1946

Cell-permeable. A potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isoforms (IC₅₀ = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively). It inhibits protein kinase A (PKA) (IC₅₀ = 0.9 μM) and calcium/calmodulin kinase II (IC₅₀ = 17 μM) at much higher concentrations. Also inhibits glycogen synthase kinase-3 (GSK-3) (IC₅₀ = 6.8 nM).

Ro 31-8220 methanesulfonate is a potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isoforms (IC₅₀ = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively). It inhibits protein kinase A (PKA) (IC₅₀ = 0.9 μM) and calcium/calmodulin kinase II (IC₅₀ = 17 μM) at much higher concentrations.

1946 | Ro 31-8220 methanesulfonate DataSheet

Alternate Name/Synonyms: 2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate; Bisindolylmaleimide IX methanesulfonate; BIM IX

Appearance: Red solid

Formulation: N/A

CAS Number: 138489-18-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₃N₅O₂S.CH₄O₃S

Molecular Weight: 553.65

Cell-Permeable?: Yes

Purity: ≥98% by NMR

Solubilities: DMSO (~ 100 mg/ml) or water (~ 5 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A potent PKC inhibitor

MDL Number: MFCD03788207

PubChem CID: 11628205

SMILES: CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O

InChi: InChI=1S/C25H23N5O2S.CH4O3S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20;1-5(2,3)4/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32);1H3,(H,2,3,4)

InChi Key: SAWVGDJBSPLRRB-UHFFFAOYSA-N