Ro 61-8048 | 1912

Cell-permeable. A high-affinity small molecule inhibitor of KMO (kynurenine 3-monoxygenase or kynurenine 3-hydroxylase)(Ki = 4.8 nM, IC₅₀ = 37 nM).

Ro 61-8048 is a high-affinity small molecule inhibitor of KMO (kynurenine 3-monoxygenase or kynurenine 3-hydroxylase)(Ki = 4.8 nM, IC₅₀ = 37 nM).

1912 | Ro 61-8048 DataSheet

Alternate Name/Synonyms: 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: 199666-03-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₅N₃O₆S₂

Molecular Weight: 421.45

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mM) or EtOH (10 mM)

Handling: Protect from light

Country of Origin: USA

Tag Line: An inhibitor of KMO (kynurenine 3-monoxygenase or kynurenine 3-hydroxylase

MDL Number: MFCD11040807

PubChem CID: 5282337

SMILES: COC1=C(C=C(C=C1)S(=O)(=O)NC2=NC(=CS2)C3=CC(=CC=C3)[N+](=O)[O-])OC

InChi: InChI=1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19)

InChi Key: NDPBMCKQJOZAQX-UHFFFAOYSA-N