Ro3280 | B1175

RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1 (IC₅₀ = 3 nM).

RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1 (IC₅₀ = 3 nM).

B1175 | Ro3280 DataSheet

Alternate Name/Synonyms: 4-((9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1062243-51-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₇H₃₅F₂N₇O₃

Molecular Weight: 543.61

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, highly selective inhibitor of Polo-like kinase 1

MDL Number: N/A

PubChem CID: 25015677

SMILES: CN1CCC(CC1)NC(=O)C2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(CC(C(=O)N4C)(F)F)C5CCCC5)OC

InChi: InChI=1S/C27H35F2N7O3/c1-34-12-10-18(11-13-34)31-24(37)17-8-9-20(22(14-17)39-3)32-26-30-15-21-23(33-26)36(19-6-4-5-7-19)16-27(28,29)25(38)35(21)2/h8-9,14-15,18-19H,4-7,10-13,16H2,1-3H3,(H,31,37)(H,30,32,33)

InChi Key: DJNZZLZKAXGMMC-UHFFFAOYSA-N