RO8994 | B1830

RO8994 is a highly potent and selective spiroindolinone small-molecule MDM2 inhibitor, with IC₅₀ of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).

RO8994 is a highly potent and selective spiroindolinone small-molecule MDM2 inhibitor, with IC₅₀ of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).

B1830 | RO8994 DataSheet

Alternate Name/Synonyms: (2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1309684-94-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₃₁H₃₁Cl₂FN₄O₄

Molecular Weight: 613.51

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A highly potent and selective small-molecule MDM2 inhibitor,

MDL Number: N/A

PubChem CID: 53238217

SMILES: CC(C)(C)CC1C2(C(C(N1)C(=O)NC3=C(C=C(C=C3)C(=O)N)OC)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O

InChi: InChI=1S/C31H31Cl2FN4O4/c1-30(2,3)14-23-31(18-10-9-16(32)13-21(18)37-29(31)41)24(17-6-5-7-19(33)25(17)34)26(38-23)28(40)36-20-11-8-15(27(35)39)12-22(20)42-4/h5-13,23-24,26,38H,14H2,1-4H3,(H2,35,39)(H,36,40)(H,37,41)/t23-,24-,26+,31+/m0/s1

InChi Key: MURAVORBGFDSMA-ISKXDESKSA-N