Robotnikinin | 1923

A small-molecule chemical inhibitor of Sonic hedgehog (Shh) signaling, that blocks hedgehog signaling through specific binding and blockade of Shh signaling factor. It is the first-characterized hedgehog inhibitor whose molecular mechanism of action is through blockade of Shh protein and not a subsequent factor of the hedgehog signaling cascades. Robotnikinin binds to the Shh-N terminal protein in a concentration-dependent fashion with a Kd of 9 µM.

Robotnikinin is a small-molecule chemical inhibitor of Sonic hedgehog (Shh) signaling, that blocks hedgehog signaling through specific binding and blockade of Shh signaling factor. It is the first-characterized hedgehog inhibitor whose molecular mechanism of action is through blockade of Shh protein and not a subsequent factor of the hedgehog signaling cascades. Robotnikinin binds to the Shh-N terminal protein in a concentration-dependent fashion with a Kd of 9 µM.

1923 | Robotnikinin DataSheet

Alternate Name/Synonyms: N-[(4-Chlorophenyl)methyl]-2-[(2R,6S,8E)-5, 12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide

Appearance: White solid

Formulation: N/A

CAS Number: 1132653-79-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₇ClN₂O₄

Molecular Weight: 454.95

Cell-Permeable?: Yes

Purity: ≥97% by NMR

Solubilities: DMSO

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A small-molecule chemical inhibitor of Sonic hedgehog (Shh) signaling

MDL Number: N/A

PubChem CID: 25109985

SMILES: C1CC(=O)OC(CNC(=O)C(CC=C1)CC(=O)NCC2=CC=C(C=C2)Cl)C3=CC=CC=C3

InChi: InChI=1S/C25H27ClN2O4/c26-21-13-11-18(12-14-21)16-27-23(29)15-20-9-5-2-6-10-24(30)32-22(17-28-25(20)31)19-7-3-1-4-8-19/h1-5,7-8,11-14,20,22H,6,9-10,15-17H2,(H,27,29)(H,28,31)/b5-2+/t20-,22-/m0/s1

InChi Key: DRDSZZCLAHXSAE-BQIDRLATSA-N