ROCK-II Inhibitor | B2934

ROCK Inhibitor-II inhibits the Rho kinase ROCK-II with an IC₅₀ <1 nM. It inhibits the cell based Myosin Light Chain (MLC) bisphosphorylation with an IC₅₀ of 7 nM.

ROCK Inhibitor-II inhibits the Rho kinase ROCK-II with an IC₅₀ <1 nM. It inhibits the cell based Myosin Light Chain (MLC) bisphosphorylation with an IC₅₀ of 7 nM.

B2934 | ROCK-II Inhibitor DataSheet

Alternate Name/Synonyms: 3-(4-(1H-pyrazol-4-yl)-2-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(3-methoxybenzyl)-1-methylurea; N-[(3-methoxyphenyl)methyl]-N-methyl-N'-[4-(1H-pyrazol-4-yl)-2-[2-(1-pyrrolidinyl)ethoxy]phenyl]-Urea; 1-[(3-methoxyphenyl)methyl]-1-methyl-3-[4-(1H-pyrazol-4-yl)-2-(2-pyrrolidin-1-ylethoxy)phenyl]urea; 1-(3-Methoxy-benzyl)-1-methyl-3-[4-(1H-pyrazol-4-yl)-2-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-urea

Appearance: Solid

Formulation:

CAS Number: 1225199-26-7

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₅H₃₁N₅O₃

Molecular Weight: 449.55

Cell-Permeable?: True

Purity: 95%

Solubilities: Soluble in DMSO in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of ROCK-II

MDL Number:

PubChem CID:

SMILES: O=C(NC1=CC=C(C2=CNN=C2)C=C1OCCN3CCCC3)N(CC4=CC=CC(OC)=C4)C

InChi: InChI=1S/C25H31N5O3/c1-29(18-19-6-5-7-22(14-19)32-2)25(31)28-23-9-8-20(21-16-26-27-17-21)15-24(23)33-13-12-30-10-3-4-11-30/h5-9,14-17H,3-4,10-13,18H2,1-2H3,(H,26,27)(H,28,31)

InChi Key: IZMNGXVMYXHMOP-UHFFFAOYSA-N