Rofecoxib | B1982

Rofecoxib is a non-steroidal anti-inflammatory drug (NSAID) that acts as a potent cyclooxygenase-2 (COX-2) inhibitor. It displays 1,000-fold selectivity for COX-2 over that of COX-1 (IC₅₀s = 26 nM and > 50 µM in human osteosarcoma cells).

Rofecoxib is a non-steroidal anti-inflammatory drug (NSAID) that acts as a potent cyclooxygenase-2 (COX-2) inhibitor. It displays 1,000-fold selectivity for COX-2 over that of COX-1 (IC₅₀s = 26 nM and > 50 µM in human osteosarcoma cells).

B1982 | Rofecoxib DataSheet

Alternate Name/Synonyms: 4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one; MK-966; MK966

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 162011-90-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₄O₄S

Molecular Weight: 314.36

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A non-steroidal anti-inflammatory drug (NSAID) and a potent cyclooxygenase-2 (COX-2) inhibitor

MDL Number: N/A

PubChem CID: 5090

SMILES: CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3

InChi: InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3

InChi Key: RZJQGNCSTQAWON-UHFFFAOYSA-N