Rose bengal | 2587

Cell-permeable. Rose Bengal is a polyhalogenated fluorescein derivative that acts as a potent inhibitor (K(i) = 19 nM) of glutamate uptake into isolated synaptic vesicles. This vesicular Glu uptake inhibition was achieved largely without affecting H(⁺)-pump ATPase.

Rose Bengal is a polyhalogenated fluorescein derivative that acts as a potent inhibitor (K(i) = 19 nM) of glutamate uptake into isolated synaptic vesicles. This vesicular Glu uptake inhibition was achieved largely without affecting H(⁺)-pump ATPase.

2587 | Rose bengal DataSheet

Alternate Name/Synonyms: 4,5,6,7-Tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one disodium salt; Rose Bengal sodium salt; Acid Red 94

Appearance: Red solid

Formulation: N/A

CAS Number: 632-69-9

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂Cl₄I₄Na₂O5

Molecular Weight: 1017.64

Cell-Permeable?: Yes

Purity: lambda max: 547.0-551.0 nm (0.02 M Ammonium acetate)

Solubilities: H₂O (~ 100 mg/ml) or DMSO (~50 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent glutamate uptake inhibitor

MDL Number: MFCD00005043

PubChem CID: 69438

SMILES: C1=C2C(=C(C(=C1I)[O-])I)OC3=C(C(=C(C=C3C24C5=C(C(=C(C(=C5Cl)Cl)Cl)Cl)C(=O)O4)I)[O-])I.[Na+].[Na+]

InChi: InChI=1S/C20H4Cl4I4O5.2Na/c21-9-7-8(10(22)12(24)11(9)23)20(33-19(7)31)3-1-5(25)15(29)13(27)17(3)32-18-4(20)2-6(26)16(30)14(18)28;;/h1-2,29-30H;;/q;2*+1/p-2

InChi Key: KCQREHTWEUECQT-UHFFFAOYSA-L