Description
RWJ-67657 is a potent inhibitor of the MAP kinases p38α and p38β (IC₅₀s = 1 and 11 µM, respectively, in vitro); inactive against p38γ and p38δ, as well as several other kinases. RWJ-67657 blocks the release of TNF-α and IL-1β from peripheral blood mononuclear cells stimulated with LPS (IC₅₀s = 3 and 11 nM, respectively) and inhibits TNF-α production in LPS-treated mice and rats.
RWJ-67657 is a potent inhibitor of the MAP kinases p38α and p38β (IC₅₀s = 1 and 11 µM, respectively, in vitro); inactive against p38γ and p38δ, as well as several other kinases. RWJ-67657 blocks the release of TNF-α and IL-1β from peripheral blood mononuclear cells stimulated with LPS (IC₅₀s = 3 and 11 nM, respectively) and inhibits TNF-α production in LPS-treated mice and rats.
Alternate Name/Synonyms: 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol
Appearance: White solid
Formulation: N/A
CAS Number: 215303-72-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₇H₂₄FN₃O
Molecular Weight: 425.5
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>40 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent inhibitor of the MAP kinases p38α and p38β
MDL Number: MFCD11840606
PubChem CID: 3008319
SMILES: C1=CC=C(C=C1)CCCN2C(=NC(=C2C3=CC=NC=C3)C4=CC=C(C=C4)F)C#CCCO
InChi: InChI=1S/C27H24FN3O/c28-24-13-11-22(12-14-24)26-27(23-15-17-29-18-16-23)31(25(30-26)10-4-5-20-32)19-6-9-21-7-2-1-3-8-21/h1-3,7-8,11-18,32H,5-6,9,19-20H2
InChi Key: QSUSKMBNZQHHPA-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |