Ryanodine | 2489

Ryanodine is a naturally occurring poisonous alkaloid that acts as a potent inhibitor of Ca²⁺ release from sarcoplasmic reticulum (IC₅₀s = 10 and 2.8 nM in skeletal and cardiac muscle, respectively). At micromolar (~100 μM) concentrations, ryanodine irreversibly inhibits ryanodine receptor channel opening, which results in paralysis.

Ryanodine is a naturally occurring poisonous alkaloid that acts as a potent inhibitor of Ca²⁺ release from sarcoplasmic reticulum (IC₅₀s = 10 and 2.8 nM in skeletal and cardiac muscle, respectively). At micromolar (~100 μM) concentrations, ryanodine irreversibly inhibits ryanodine receptor channel opening, which results in paralysis.

2489 | Ryanodine DataSheet

Alternate Name/Synonyms: (3S,​4R,​4aR,​6S,​6aS,​7S,​8R,​8aS,​8bR,​9S,​9aS)-​dodecahydro-​4,​6,​7,​8a,​8b,​9a-​hexahydroxy-​3,​6a,​9-​trimethyl-​7-​(1-​methylethyl)-​6,​9-​methanobenzo[1,​2]pentaleno[1,​6-​bc]furan-​8-​yl ester-​1H-​pyrrole-​2-​carboxylic acid

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 15662-33-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₃₅NO₉

Molecular Weight: 493.55

Cell-Permeable?: No

Purity: ≥98%

Solubilities: DMSO (>10 mg/ml) or EtOH (~5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An potent inhibitor of Ca²⁺ release

MDL Number: MFCD00151119

PubChem CID: 11317883

SMILES: CC1CCC2(C3(CC4(C5(C(C(C3(C5(C2(C1O)O4)O)O)OC(=O)C6=CC=CN6)(C(C)C)O)C)O)C)O

InChi: InChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19+,20-,21-,22+,23+,24+,25+/m0/s1

InChi Key: JJSYXNQGLHBRRK-SFEDZAPPSA-N