Salubrinal | 1980

Cell-permeable. A selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Also protects cells from endoplasmic reticulum stress-induced apoptosis (EC₅₀ ~ 15 μM).

Salubrinal is a selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Also protects cells from endoplasmic reticulum stress-induced apoptosis (EC₅₀ ~ 15 μM).

1980 | Salubrinal DataSheet

Alternate Name/Synonyms: N-(2,2,2-trichloro-1-(3-quinolin-8-lthioureido)ethyl)cinnamamide; SAL; eIF-2α Inhibitor

Appearance: Beige solid

Formulation: N/A

CAS Number: 405060-95-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₇Cl₃N₄OS

Molecular Weight: 479.81

Cell-Permeable?: Yes

Purity: ≥90% by HPLC

Solubilities: DMSO ( 100 mM)

Handling: Protect from light and mositure

Country of Origin: USA

Tag Line: A selective eIF-2α inhibitor

MDL Number: MFCD00548612

PubChem CID: 5717801

SMILES: C1=CC=C(C=C1)C=CC(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3

InChi: InChI=1S/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+

InChi Key: LCOIAYJMPKXARU-VAWYXSNFSA-N