Description
Cell-permeable. A potent antagonist of Hedgehog (Hh) signaling pathway. Antagonizes smoothened receptor activity (KD = 12 nM) and inhibits SAG (Cat. No. 1939-500,1000) activity. SANT-2 should be a useful tool to study the Hh signaling pathway.
SANT-2 is a potent antagonist of Hedgehog (Hh) signaling pathway. Antagonizes smoothened receptor activity (KD = 12 nM) and inhibits SAG (Cat. No. 1939-500,1000) activity. SANT-2 should be a useful tool to study the Hh signaling pathway.
Alternate Name/Synonyms: N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 329196-48-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₆H₂₆ClN₃O₄
Molecular Weight: 479.96
Cell-Permeable?: Yes
Purity: ≥95% by NMR
Solubilities: DMSO (100 mM) or EtOH (100 mM)
Handling: Protect from light
Country of Origin: USA
Tag Line: A potent Hedgehog (Hh) signaling pathway antagonist
MDL Number: N/A
PubChem CID: 1367095
SMILES: CCOC1=CC(=CC(=C1OCC)OCC)C(=O)NC2=CC(=C(C=C2)Cl)C3=NC4=CC=CC=C4N3
InChi: InChI=1S/C26H26ClN3O4/c1-4-32-22-13-16(14-23(33-5-2)24(22)34-6-3)26(31)28-17-11-12-19(27)18(15-17)25-29-20-9-7-8-10-21(20)30-25/h7-15H,4-6H2,1-3H3,(H,28,31)(H,29,30)
InChi Key: VQOJFGFKIVFMDH-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
48 months |