SAR-260301 | B1263

SAR260301 is a potent and selective Class I phosphatidylinositol-3-kinase-β (PI3K-β) specific inhibitor with an IC₅₀ of 52 nM for this isoform. SAR260301 displays improved physicochemical and in vitro pharmacokinetic properties.

SAR260301 is a potent and selective Class I phosphatidylinositol-3-kinase-β (PI3K-β) specific inhibitor with an IC₅₀ of 52 nM for this isoform. SAR260301 displays improved physicochemical and in vitro pharmacokinetic properties.

B1263 | SAR-260301 DataSheet

Alternate Name/Synonyms: (S)-2-(2-(2-methylindolin-1-yl)-2-oxoethyl)-6-morpholinopyrimidin-4(3H)-one

Appearance: Crystaline solid

Formulation: N/A

CAS Number: 1260612-13-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₉H₂₂N₄O₃

Molecular Weight: 354.4

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective Class I phosphatidylinositol-3-kinase-β (PI3K-β) specific inhibitor

MDL Number: MFCD27987912

PubChem CID: 49854424

SMILES: CC1CC2=CC=CC=C2N1C(=O)CC3=NC(=O)C=C(N3)N4CCOCC4

InChi: InChI=1S/C19H22N4O3/c1-13-10-14-4-2-3-5-15(14)23(13)19(25)11-16-20-17(12-18(24)21-16)22-6-8-26-9-7-22/h2-5,12-13H,6-11H2,1H3,(H,20,21,24)/t13-/m0/s1

InChi Key: UAXHPOBBKRWJGA-ZDUSSCGKSA-N