Description
SB-204490 is a potent and specific ATP citrate lyase (ACLY) inhibitor. Prodrug of SB-201076. Inhibits cholesterol and fatty acid synthesis in a dose-dependent manner in HepG2 cells.
SB-204490 is a potent and specific ATP citrate lyase (ACLY) inhibitor. Prodrug of SB-201076. Inhibits cholesterol and fatty acid synthesis in a dose-dependent manner in HepG2 cells.
Alternate Name/Synonyms: SB204490; (3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid
Appearance: White solid
Formulation:
CAS Number: 154566-12-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₂₂Cl₂O₅
Molecular Weight: 389.27
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: >35 mg/ml in Ethanol, >35 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent and specific inhibitor of ATP citrate lyase (ACLY).
MDL Number:
PubChem CID: 10340264
SMILES: C1C(OC(=O)C1(CC(=O)O)O)CCCCCCC2=C(C=C(C=C2)Cl)Cl
InChi: InChI=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21)22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18+/m1/s1
InChi Key: YTRNLFYTHYWDAU-KDOFPFPSSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |
