SB 216763 | 1769

A potent, cell-permeable and ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3) (Ki= 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC₅₀ > 10 μM). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

SB 216763 is a potent, cell-permeable and ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3) (Ki= 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC₅₀ > 10 μM). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

1769 | SB 216763 DataSheet

Alternate Name/Synonyms: 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Appearance: Orange solid

Formulation: N/A

CAS Number: 280744-09-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₂Cl₂N₂O₂

Molecular Weight: 371.22

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (50 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A GSK-3 inhibitor

MDL Number: MFCD09753369

PubChem CID: 176158

SMILES: CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C(C=C(C=C4)Cl)Cl

InChi: InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)

InChi Key: JCSGFHVFHSKIJH-UHFFFAOYSA-N