SB-265610 | B3283

SB-265610 is a potent and selective CXCR2 chemokine receptor antagonist (Kd = 2.5 nM). It does not bind to CXCR1). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo.

SB-265610 is a potent and selective CXCR2 chemokine receptor antagonist (Kd = 2.5 nM). It does not bind to CXCR1). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo.

B3283 | SB-265610 DataSheet

Alternate Name/Synonyms: SB265610 N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea

Appearance: Off-white solid

Formulation:

CAS Number: 211096-49-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₉BrN₆O

Molecular Weight: 357.16

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >30 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent CXCR2 antagonist

MDL Number: MFCD09971124

PubChem CID: 9841667

SMILES: O=C(NC3=C(Br)C=CC=C3)NC1=CC=C(C#N)C2=C1NN=N2

InChi: InChI=1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21)

InChi Key: SEDUMQWZEOMXSO-UHFFFAOYSA-N