Description
SB-265610 is a potent and selective CXCR2 chemokine receptor antagonist (Kd = 2.5 nM). It does not bind to CXCR1). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo.
SB-265610 is a potent and selective CXCR2 chemokine receptor antagonist (Kd = 2.5 nM). It does not bind to CXCR1). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo.
Alternate Name/Synonyms: SB265610 N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea
Appearance: Off-white solid
Formulation:
CAS Number: 211096-49-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₄H₉BrN₆O
Molecular Weight: 357.16
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: >30 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent CXCR2 antagonist
MDL Number: MFCD09971124
PubChem CID: 9841667
SMILES: O=C(NC3=C(Br)C=CC=C3)NC1=CC=C(C#N)C2=C1NN=N2
InChi: InChI=1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21)
InChi Key: SEDUMQWZEOMXSO-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |