SB 939 | 2285

An orally available pan-histone deacetylase (HDAC) inhibitor binding all HDAC isozymes with similar affinity (Kis = 16-28 nM) with the exception of HDAC6 and 7 (Kis = 247 and 104 nM, respectively). SB 939 demonstrates good bioavailability in vivo and significantly inhibits tumor growth in various xenograft mouse models at doses ranging from 25-100 mg/kg.

SB 939 is a pan-histone deacetylase (HDAC) inhibitor binding all HDAC isozymes with similar affinity (Kis = 16-28 nM) with the exception of HDAC6 and 7 (Kis = 247 and 104 nM, respectively).

2285 | SB 939 DataSheet

Alternate Name/Synonyms: 3-​[2-​butyl-​1-​[2-​(diethylamino)ethyl]-​1H-​benzimidazol-​5-​yl]-​N-​hydroxy-​2E-​propenamide; Pracinostat

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 929016-96-6

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₂₀H₃₀N₄O₂

Molecular Weight: 358.48

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A pan-HDAC inhibitor

MDL Number: N/A

PubChem CID: 49855250

SMILES: CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)C=CC(=O)NO

InChi: InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+

InChi Key: JHDKZFFAIZKUCU-ZRDIBKRKSA-N