Description
SBE13 HCl is a potent and selective PLK1 (Polo-like kinase 1) inhibitor (IC₅₀ = 200 pM). Displays activity against PLK2 and PLK3 at higher concentrations (IC₅₀ values of 66 µM and 875 nM, respectively). Has no effect on Aurora kinase A.
SBE13 HCl is a potent and selective PLK1 (Polo-like kinase 1) inhibitor (IC₅₀ = 200 pM). Displays activity against PLK2 and PLK3 at higher concentrations (IC₅₀ values of 66 µM and 875 nM, respectively). Has no effect on Aurora kinase A.
2847 | SBE13 hydrochloride DataSheet
Alternate Name/Synonyms: N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxybenzeneethanamine hydrochloride
Appearance: White solid
Formulation: N/A
CAS Number: 1052532-15-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₂₇ClN₂O₄.HCl
Molecular Weight: 479.4
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>40 mg/ml) or H2O (~4 mg/ml with slight warming)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A potent and selective PLK1 (Polo-like kinase 1) inhibitor
MDL Number: MFCD20036266
PubChem CID: 11948807
SMILES: COC1=C(C=C(C=C1)CCNCC2=CC(=C(C=C2)OCC3=CN=C(C=C3)Cl)OC)OC.Cl
InChi: InChI=1S/C24H27ClN2O4.ClH/c1-28-20-7-4-17(12-22(20)29-2)10-11-26-14-18-5-8-21(23(13-18)30-3)31-16-19-6-9-24(25)27-15-19;/h4-9,12-13,15,26H,10-11,14,16H2,1-3H3;1H
InChi Key: QBGSVDJLQQXEGG-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |