SBE13 hydrochloride | 2847

SBE13 HCl is a potent and selective PLK1 (Polo-like kinase 1) inhibitor (IC₅₀ = 200 pM). Displays activity against PLK2 and PLK3 at higher concentrations (IC₅₀ values of 66 µM and 875 nM, respectively). Has no effect on Aurora kinase A.

SBE13 HCl is a potent and selective PLK1 (Polo-like kinase 1) inhibitor (IC₅₀ = 200 pM). Displays activity against PLK2 and PLK3 at higher concentrations (IC₅₀ values of 66 µM and 875 nM, respectively). Has no effect on Aurora kinase A.

2847 | SBE13 hydrochloride DataSheet

Alternate Name/Synonyms: N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxybenzeneethanamine hydrochloride

Appearance: White solid

Formulation: N/A

CAS Number: 1052532-15-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₇ClN₂O₄.HCl

Molecular Weight: 479.4

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>40 mg/ml) or H2O (~4 mg/ml with slight warming)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent and selective PLK1 (Polo-like kinase 1) inhibitor

MDL Number: MFCD20036266

PubChem CID: 11948807

SMILES: COC1=C(C=C(C=C1)CCNCC2=CC(=C(C=C2)OCC3=CN=C(C=C3)Cl)OC)OC.Cl

InChi: InChI=1S/C24H27ClN2O4.ClH/c1-28-20-7-4-17(12-22(20)29-2)10-11-26-14-18-5-8-21(23(13-18)30-3)31-16-19-6-9-24(25)27-15-19;/h4-9,12-13,15,26H,10-11,14,16H2,1-3H3;1H

InChi Key: QBGSVDJLQQXEGG-UHFFFAOYSA-N