Description
SBHA is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC₅₀ = 0.25 μM) and HDAC3 (IC₅₀ = 0.30 μM). SBHA causes cell differentiation, cell cycle arrest, or apoptosis. SBHA also enhances cytotoxicity induced by Oxaliplatin in the colorectal cancer cell lines.
SBHA is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC₅₀ = 0.25 μM) and HDAC3 (IC₅₀ = 0.30 μM).
Alternate Name/Synonyms: Suberohydroxamic acid; suberic bis-hydroxamic acid; N,N'-dihydroxyoctanediamide
Appearance: White to Off-white Solid
Formulation: N/A
CAS Number: 38937-66-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₈H₁₆N₂O₄
Molecular Weight: 204.22
Cell-Permeable?: Yes
Purity: ≥95% by TLC
Solubilities: H2O (100 mM) or DMSO (100 mM)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent HDAC inhibitor
MDL Number: MFCD00192455
PubChem CID: 5173
SMILES: C(CCCC(=O)NO)CCC(=O)NO
InChi: InChI=1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)
InChi Key: IDQPVOFTURLJPT-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24months |