SC-26196 | B1580

SC-26196 is a selective Δ6 desaturase inhibitor (IC₅₀ = 0.2 μM in vitro. It displays selectivity over Δ5 and Δ9 desaturases (IC₅₀ values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro. SC-26196 is orally active in vivo, decreasing edema in the carrageenan paw edema model in mice.

SC-26196 is a selective Δ6 desaturase inhibitor (IC₅₀ = 0.2 μM in vitro. It displays selectivity over Δ5 and Δ9 desaturases (IC₅₀ values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro. SC-26196 is orally active in vivo, decreasing edema in the carrageenan paw edema model in mice.

B1580 | SC-26196 DataSheet

Alternate Name/Synonyms: 2,2-diphenyl-5-[4-(pyridin-3-ylmethylideneamino)piperazin-1-yl]pentanenitrile

Appearance: Beige solid

Formulation: N/A

CAS Number: 218136-59-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₇H₂₉N₅

Molecular Weight: 423.55

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective Δ6 desaturase inhibitor

MDL Number: MFCD11226148

PubChem CID: 9845201

SMILES: C1CN(CCN1CCCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)N=CC4=CN=CC=C4

InChi: C1CN(CCN1CCCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)/N=C/C4=CN=CC=C4

InChi Key: QFYKXKMYVYOUNJ-JBASAIQMSA-N