SC66 | 1870

Cell-permeable. An allosteic Akt inhibitor that directly facilitates Akt ubiquitination in vitro and in vivo. SC66 displays a dual inhibitory activity that directly interferes with the pleckstrin homology (PH) domain binding to PIP₃ and facilitates Akt ubiquitination. Due to its dual inhibitory activity, SC66 displays a more effective growth suppression of transformed cells that contain a high level of Akt signaling, compared with other inhibitors of PIP₃/Akt pathway.

SC66 is an allosteic Akt inhibitor that directly facilitates Akt ubiquitination in vitro and in vivo. SC66 displays a dual inhibitory activity that directly interferes with the pleckstrin homology (PH) domain binding to PIP₃ and facilitates Akt ubiquitination. Due to its dual inhibitory activity, SC66 displays a more effective growth suppression of transformed cells that contain a high level of Akt signaling, compared with other inhibitors of PIP₃/Akt pathway.

1870 | SC66 DataSheet

Alternate Name/Synonyms: (2E, 6E)-2, 6-Bis(pyridine-4ylmethylene)cyclohexanone

Appearance: Yellow crystalline solid

Formulation: N/A

CAS Number: 871361-88-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₆N₂O

Molecular Weight: 276.33

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An allosteric Akt inhibitor

MDL Number: MFCD05025493

PubChem CID: 6018993

SMILES: C1CC(=CC2=CC=NC=C2)C(=O)C(=CC3=CC=NC=C3)C1

InChi: InChI=1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+

InChi Key: CYVVJSKZRBZHAV-UNZYHPAISA-N