Semagacestat | 2430

A potent γ-secretase inhibitor (IC₅₀ = 10.9 nM, 12.1 nM and 12.0 nM for Aβ42, Aβ40 and Aβ38, respectively). Semagacestat has shown to reduce the rate of formation of amyloid-β in vitro and in vivo.

Semagacestat is a potent γ-secretase inhibitor (IC₅₀ = 10.9 nM, 12.1 nM and 12.0 nM for Aβ42, Aβ40 and Aβ38, respectively).

2430 | Semagacestat DataSheet

Alternate Name/Synonyms: (S)-2-hydroxy-3-methyl-N-((S)-1-((S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino)-1-oxopropan-2-yl)butanamide ; LY450139

Appearance: White solid

Formulation: N/A

CAS Number: 425386-60-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₇N₃O₄

Molecular Weight: 361.44

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>60 mg/ml) or EtOH (>40 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A potent γ-secretase inhibitor

MDL Number: N/A

PubChem CID: 9843750

SMILES: CC(C)C(C(=O)NC(C)C(=O)NC1C2=CC=CC=C2CCN(C1=O)C)O

InChi: InChI=1S/C19H27N3O4/c1-11(2)16(23)18(25)20-12(3)17(24)21-15-14-8-6-5-7-13(14)9-10-22(4)19(15)26/h5-8,11-12,15-16,23H,9-10H2,1-4H3,(H,20,25)(H,21,24)/t12-,15-,16-/m0/s1

InChi Key: PKXWXXPNHIWQHW-RCBQFDQVSA-N