Description
Serabelisib is a potent inhibitor of phosphoinositide 3-kinase α (PI3Kα) that is selective for p110α in vitro (IC₅₀ = 15 nM for PI3Kα vs. >1 µM for other isoforms, as well as for mTOR). MLN1117 inhibits AKT phosphorylation and growth in PIK3CA mutant breast cancer cells with IC₅₀ values around 2 μM, yet has no effect on cells lacking PTEN.
Serabelisib is a potent inhibitor of phosphoinositide 3-kinase α (PI3Kα) that is selective for p110α in vitro (IC₅₀ = 15 nM for PI3Kα vs. >1 µM for other isoforms, as well as for mTOR). MLN1117 inhibits AKT phosphorylation and growth in PIK3CA mutant breast cancer cells with IC₅₀ values around 2 μM, yet has no effect on cells lacking PTEN.
Alternate Name/Synonyms: [6-(2-amino-5-benzoxazolyl)imidazo[1,2-a]pyridin-3-yl]-4-morpholinyl-methanone; MLN1117, INK1117, TAK-117)
Appearance: Brown solid
Formulation: N/A
CAS Number: 1268454-23-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₁₇N₅O₃
Molecular Weight: 363.34
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~1 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent inhibitor of phosphoinositide 3-kinase α (PI3Kα) inhibitor
MDL Number: N/A
PubChem CID: 70798655
SMILES: C1COCCN1C(=O)C2=CN=C3N2C=C(C=C3)C4=CC5=C(C=C4)OC(=N5)N
InChi: InChI=1S/C19H17N5O3/c20-19-22-14-
InChi Key: BLGWHBSBBJNKJO-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |