Serabelisib | B1930

Serabelisib is a potent inhibitor of phosphoinositide 3-kinase α (PI3Kα) that is selective for p110α in vitro (IC₅₀ = 15 nM for PI3Kα vs. >1 µM for other isoforms, as well as for mTOR). MLN1117 inhibits AKT phosphorylation and growth in PIK3CA mutant breast cancer cells with IC₅₀ values around 2 μM, yet has no effect on cells lacking PTEN.

Serabelisib is a potent inhibitor of phosphoinositide 3-kinase α (PI3Kα) that is selective for p110α in vitro (IC₅₀ = 15 nM for PI3Kα vs. >1 µM for other isoforms, as well as for mTOR). MLN1117 inhibits AKT phosphorylation and growth in PIK3CA mutant breast cancer cells with IC₅₀ values around 2 μM, yet has no effect on cells lacking PTEN.

B1930 | Serabelisib DataSheet

Alternate Name/Synonyms: [6-(2-amino-5-benzoxazolyl)imidazo[1,2-a]pyridin-3-yl]-4-morpholinyl-methanone; MLN1117, INK1117, TAK-117)

Appearance: Brown solid

Formulation: N/A

CAS Number: 1268454-23-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₇N₅O₃

Molecular Weight: 363.34

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~1 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of phosphoinositide 3-kinase α (PI3Kα) inhibitor

MDL Number: N/A

PubChem CID: 70798655

SMILES: C1COCCN1C(=O)C2=CN=C3N2C=C(C=C3)C4=CC5=C(C=C4)OC(=N5)N

InChi: InChI=1S/C19H17N5O3/c20-19-22-14-

InChi Key: BLGWHBSBBJNKJO-UHFFFAOYSA-N