SGC707 | B2846

SGC707 is a potent, selective and allosteric inhibitor of Protein arginine methyltransferase3 (PRMT3) with an IC₅₀ of 31 nM and KD of 53 nM. It inhibits the methylation of histones in cells at a concentration of 1 µM.

SGC707 is a potent, selective and allosteric inhibitor of Protein arginine methyltransferase3 (PRMT3) with an IC₅₀ of 31 nM and KD of 53 nM. It inhibits the methylation of histones in cells at a concentration of 1 µM.

B2846 | SGC707 DataSheet

Alternate Name/Synonyms: 1-isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea; N-6-Isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea; N-{2-[(2-Oxo-3-azepanyl)carbamoyl]phenyl}-1-benzothiophene-2-carboxamide

Appearance: A crystalline solid

Formulation:

CAS Number: 1687736-54-4

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₁₆H₁₈N₄O₂

Molecular Weight: 298.34

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~2 mg/ml in DMSO and DMF in 0, ~5 mg/ml in in Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of PRMT3

MDL Number:

PubChem CID: 90642938

SMILES: C1CCN(C1)C(=O)CNC(=O)NC2=CC3=C(C=C2)C=NC=C3

InChi: InChI=1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22)

InChi Key: DMIDPTCQPIJYFE-UHFFFAOYSA-N