Silvestrol | B2417

Silvestrol is a natural product isolated from the fruits and twigs of Aglaia foveolata. Acts as a eukaryotic translation initiation factor 4A (eIF4A) inhibitor. Also displays broad-spectrum antiviral activity in infected primary cells by inhibiting eIF4A-dependent viral mRNA translation.

Silvestrol is a natural product isolated from the fruits and twigs of Aglaia foveolata. Acts as a eukaryotic translation initiation factor 4A (eIF4A) inhibitor. Also displays broad-spectrum antiviral activity in infected primary cells by inhibiting eIF4A-dependent viral mRNA translation.

B2417 | Silvestrol DataSheet

Alternate Name/Synonyms: methyl (1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate, (-)-silvestrol

Appearance: Solid

Formulation:

CAS Number: 697235-38-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₄H₃₈O₁₃

Molecular Weight: 654.66

Cell-Permeable?: True

Purity: ≥95%

Solubilities: >5 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A eukaryotic translation initiation factor 4A (eIF4A) inhibitor

MDL Number:

PubChem CID: 11787114

SMILES: COC1C(OC(CO1)C(CO)O)OC2=CC(=C3C(=C2)OC4(C3(C(C(C4C5=CC=CC=C5)C(=O)OC)O)O)C6=CC=C(C=C6)OC)OC

InChi: InChI=1S/C34H38O13/c1-40-20-12-10-19(11-13-20)34-27(18-8-6-5-7-9-18)26(30(38)42-3)29(37)33(34,39)28-23(41-2)14-21(15-24(28)47-34)45-32-31(43-4)44-17-25(46-32)22(36)16-35/h5-15,22,25-27,29,31-32,35-37,39H,16-17H2,1-4H3/t22-,25-,26-,27-,29-,31-,32-,33+,34+/m1/s1

InChi Key: GVKXFVCXBFGBCD-QKDMMWSPSA-N