Sinomenine hydrochloride | B2741

Sinomenine is a natural plant alkaloid that displays anti-inflammatory properties. It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events. Sinomenine also impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain. Sinomenine potentiates renewal of human embryonic stem cells.

Sinomenine is a natural plant alkaloid that displays anti-inflammatory properties. It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events. Sinomenine also impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain. Sinomenine potentiates renewal of human embryonic stem cells.

B2741 | Sinomenine hydrochloride DataSheet

Alternate Name/Synonyms: Cucoline; (9a,13a,14a)-7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-morphinan-6-one, monohydrochloride; NSC 76021

Appearance: White to off-white solid

Formulation:

CAS Number: 6080-33-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₃NO₄ • HCl

Molecular Weight: 365.85

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~20 mg/ml Water

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An anti-inflammatory agent

MDL Number: MFCD01714307

PubChem CID: 5464452

SMILES: CN1CCC23CC(=O)C(=CC2C1CC4=C3C(=C(C=C4)OC)O)OC.Cl

InChi: InChI=1S/C19H23NO4.ClH/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19;/h4-5,9,12-13,22H,6-8,10H2,1-3H3;1H/t12-,13+,19-;/m1./s1

InChi Key: YMEVIMJAUHZFMW-VUIDNZEBSA-N