SirtACt | 2741

SirtAct is a potent Sirtuin 1 (SIRT1) activator. It increases fluorescence by 233% in a SIRT1 activity assay. SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice. It inhibits NF-κB activation and reduces inflammatory cytokine production in lamina propria mononuclear cells from IBD patients. SirtAct also prevents and cures experimental colitis in a mouse model.

SirtAct is a potent Sirtuin 1 (SIRT1) activator. It increases fluorescence by 233% in a SIRT1 activity assay. SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice. It inhibits NF-κB activation and reduces inflammatory cytokine production in lamina propria mononuclear cells from IBD patients. SirtAct also prevents and cures experimental colitis in a mouse model.

2741 | SirtACt DataSheet

Alternate Name/Synonyms: 2-​Amino-​N-​cyclopentyl-​1-​(3-​methoxypropyl)-​1H-​pyrrolo[2,​3-​b]quinoxaline-​3-​carboxamide; CAY10591; SIRT1 activator 3; Sirtuin1 Activator 3

Appearance: Olive green solid

Formulation: N/A

CAS Number: 839699-72-8

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₅N₅O₂

Molecular Weight: 367.5

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (50 mg/ml) or EtOH (20 mg/ml, warm)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent SIRT1 activator

MDL Number: N/A

PubChem CID: 35028109

SMILES: COCCCN1C(=C(C2=NC3=CC=CC=C3N=C21)C(=O)NC4CCCC4)N=N

InChi: InChI=1S/C20H24N6O2/c1-28-12-6-11-26-18(25-21)16(20(27)22-13-7-2-3-8-13)17-19(26)24-15-10-5-4-9-14(15)23-17/h4-5,9-10,13,21H,2-3,6-8,11-12H2,1H3,(H,22,27)

InChi Key: FCSPEKABVJVYEG-UHFFFAOYSA-N