Sitagliptin Phosphate Monohydrate | 1757

An anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release , stimulates the insulin release and lowers blood glucose.

Sitagliptin Phosphate Monohydrate is an anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release , stimulates the insulin release and lowers blood glucose.

1757 | Sitagliptin Phosphate Monohydrate DataSheet

Alternate Name/Synonyms: 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate; MK-0431

Appearance: White solid

Formulation: N/A

CAS Number: 654671-77-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₅F₆N₅O•H₃PO₄•H₂O

Molecular Weight: 523.32

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: H₂O

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A DPP4 inhibitor

MDL Number: MFCD10001393

PubChem CID: 11591741

SMILES: C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)CC(CC3=CC(=C(C=C3F)F)F)N.O.OP(=O)(O)O

InChi: InChI=1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4);1H2/t9-;;/m1../s1

InChi Key: GQPYTJVDPQTBQC-KLQYNRQASA-N