Smad3 Inhibitor, SIS3 | 2227

A potent and selective inhibitor of Smad3 function. SIS3 selectively inhibits TGF-β1/ALK5-induced Smad3 phosphorylation. Also inhibits the TGF-β1 effect on type I procollagen expression at the transcriptional levels via the Smad3-binding site.

SIS3 is a potent and selective inhibitor of Smad3 function. SIS3 selectively inhibits TGF-β1/ALK5-induced Smad3 phosphorylation.

2227 | Smad3 Inhibitor, SIS3 DataSheet

Alternate Name/Synonyms: (2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride

Appearance: Yellow solid

Formulation: N/A

CAS Number: 521984-48-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₂₇N₃O₃ ∙ HCl

Molecular Weight: 489.99

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A Smad3 inhibitor

MDL Number: MFCD09265258

PubChem CID: 16079005

SMILES: CN1C(=C(C2=C1N=CC=C2)C=CC(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5.Cl

InChi: InChI=1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;

InChi Key: CDKIEBFIMCSCBB-CALJPSDSSA-N