Description
SMER-3 (Small molecule enhancer of rapamycin -3) is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes that results in cell cycle arrest and blockage of cell proliferation.
SMER-3 (Small molecule enhancer of rapamycin -3) is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes that results in cell cycle arrest and blockage of cell proliferation.
Alternate Name/Synonyms: 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
Appearance: Yellow solid
Formulation: N/A
CAS Number: 67200-34-4
Structure Available?: Yes
Peptide sequence: No
Salt Form: No
Molecular Formula: C₁₁H₄N₄O₂
Molecular Weight: 224.18
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: E3 Ubiquitin Ligase Inhibitor
MDL Number: MFCD00451458
PubChem CID: 568763
SMILES: C1=CC=C2C(=C1)C3=NC4=NON=C4N=C3C2=O
InChi: InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H
InChi Key: SFSSAKVWCKFRHE-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |