SMER-3 | 2514

SMER-3 (Small molecule enhancer of rapamycin -3) is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes that results in cell cycle arrest and blockage of cell proliferation.

SMER-3 (Small molecule enhancer of rapamycin -3) is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes that results in cell cycle arrest and blockage of cell proliferation.

2514 | SMER-3 DataSheet

Alternate Name/Synonyms: 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one

Appearance: Yellow solid

Formulation: N/A

CAS Number: 67200-34-4

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₁₁H₄N₄O₂

Molecular Weight: 224.18

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: E3 Ubiquitin Ligase Inhibitor

MDL Number: MFCD00451458

PubChem CID: 568763

SMILES: C1=CC=C2C(=C1)C3=NC4=NON=C4N=C3C2=O

InChi: InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H

InChi Key: SFSSAKVWCKFRHE-UHFFFAOYSA-N