SMER28 | 1856

Cell permeable. Acts as a positive regulator of autophagy, acting via mTOR-independent mechanism. SMER28 increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. It is also protective in Drosophila model of Huntington’s Disease (HD).

SMER28 acts as a positive regulator of autophagy, acting via mTOR-independent mechanism. SMER28 increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. It is also protective in Drosophila model of Huntington’s Disease (HD).

1856 | SMER28 DataSheet

Alternate Name/Synonyms: Small-Molecule Enhancer of Rapamycin-28;6-Bromo-4-allylaminoquinazoline

Appearance: Off-white solid

Formulation: N/A

CAS Number: 307538-42-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₁H₁₀BrN₃

Molecular Weight: 264.12

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~8 mg/ml) or EtOH (~ 2 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A positive regulator of autophagy

MDL Number: MFCD02166825

PubChem CID: 1560402

SMILES: C=CCNC1=NC=NC2=C1C=C(C=C2)Br

InChi: InChI=1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)

InChi Key: BCPOLXUSCUFDGE-UHFFFAOYSA-N