SMI-4a | 2211

A selective, ATP-competitive inhibitor Pim-1 (IC₅₀ = 21 nM) and Pim-2 (IC₅₀ = 100 nM) protein kinases. Blocks mTORC1 activity via activation of AMPK. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines.

SMI-4 a is a selective, ATP-competitive inhibitor Pim-1 (IC₅₀ = 21 nM) and Pim-2 (IC₅₀ = 100 nM) protein kinases. Blocks mTORC1 activity via activation of AMPK. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines.

2211 | SMI-4a DataSheet

Alternate Name/Synonyms: 5E/Z)-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 327033-36-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₁H₆F₃NO₂S

Molecular Weight: 273.23

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A pim kinase inhibitor

MDL Number: MFCD01152003

PubChem CID: 1361334

SMILES: C1=CC(=CC(=C1)C(F)(F)F)C=C2C(=O)NC(=O)S2

InChi: InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5-

InChi Key: NGJLOFCOEOHFKQ-YVMONPNESA-N