Smo Antagonist, SA10 | 2159

SA10 inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 5 µM). However, unlike SA1 and SA9, Smo antagonist SA10 does not directly bind to Smo. Inhibits the localization o Smo to cilia. Also treatment of Ptch1-/- MEFs with SA10 suppresses the β-galactosidase activity (IC₅₀ = 11.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.

Smo Antagonist, SA10 inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 5 µM). However, unlike SA1 and SA9, Smo antagonist SA10 does not directly bind to Smo. Inhibits the localization o Smo to cilia. Also treatment of Ptch1-/- MEFs with SA10 suppresses the β-galactosidase activity (IC₅₀ = 11.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.

2159 | Smo Antagonist, SA10 DataSheet

Alternate Name/Synonyms: 4-((Benzo[c][1,2,5]thiadiazole-4-sulfonamido)methyl-N-(3-phenylpropyl)cyclohexanecarboxamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₈N₄O₃S₂

Molecular Weight: 472.62

Cell-Permeable?: Yes

Purity: ≥95% by NMR

Solubilities: DMSO

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A Hedgehog (Hh) signaling pathway antagonist

MDL Number: N/A

PubChem CID: N/A

SMILES: N/A

InChi: N/A

InChi Key: N/A