Smo Antagonist, SA9 | 2155

SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 19 µM). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the β-galactosidase activity (IC₅₀ = 1.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.

Smo Antagonist, SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 19 µM). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the β-galactosidase activity (IC₅₀ = 1.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.

2155 | Smo Antagonist, SA9 DataSheet

Alternate Name/Synonyms: 3-(3-(4-Fluorophenyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl-N-(3-methylphenethyl)propanamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₈ClN₅O₂

Molecular Weight: 490

Cell-Permeable?: Yes

Purity: ≥95% by NMR

Solubilities: DMSO

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A Hedgehog (Hh) signaling pathway antagonist

MDL Number: N/A

PubChem CID: 20880974

SMILES: C1CCC(=CC1)CCNC(=O)CCC2=NN=C3N2C4=CC=CC=C4C(=O)N3CC5=CC=C(C=C5)Cl

InChi: InChI=1S/C27H28ClN5O2/c28-21-12-10-20(11-13-21)18-32-26(35)22-8-4-5-9-23(22)33-24(30-31-27(32)33)14-15-25(34)29-17-16-19-6-2-1-3-7-19/h4-6,8-13H,1-3,7,14-18H2,(H,29,34)

InChi Key: YTDIPVZSLXYGNL-UHFFFAOYSA-N