Description
SNS-032 is a potent CDK inhibitor. Inhibits cyclin-dependent kinases (cdks) 9, 2 and 7 with IC₅₀ values of 4, 38 and 62 nM respectively. Displays no activity against 190 additional kinases (IC₅₀ >1000 nM). Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.
SNS-032 is a potent CDK inhibitor. Inhibits cyclin-dependent kinases (cdks) 9, 2 and 7 with IC₅₀ values of 4, 38 and 62 nM respectively. Displays no activity against 190 additional kinases (IC₅₀ >1000 nM). Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.
Alternate Name/Synonyms: N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide; BMS-387032
Appearance: White solid
Formulation: N/A
CAS Number: 345627-80-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₇H₂₄N₄O₂S₂
Molecular Weight: 380.53
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>15 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent CDK (cyclin-dependent kinase) inhibitor
MDL Number: N/A
PubChem CID: 3025986
SMILES: CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3
InChi: InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)
InChi Key: OUSFTKFNBAZUKL-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |