Description
A potent pan-Aurora kinase inhibitor. Inhibits Aurora kinases A, B, and C with IC₅₀ values of 9 nM, 31 nM and 3 nM, respectively. Displays potent anti-tumor activity.
SNS-314 is a potent pan-Aurora kinase inhibitor. Inhibits Aurora kinases A, B, and C with IC₅₀values of 9 nM, 31 nM and 3 nM, respectively.
Alternate Name/Synonyms: (3-chlorophenyl)-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea mesyalte
Appearance: Light yellow solid
Formulation: N/A
CAS Number: 1057249-41-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₁₅ClN₆OS₂
Molecular Weight: 430.93
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>50 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A potent pan-Aurora kinase inhibitor.
MDL Number: N/A
PubChem CID: 24995524
SMILES: C1=CC(=CC(=C1)Cl)NC(=O)NC2=NC=C(S2)CCNC3=NC=NC4=C3SC=C4
InChi: InChI=1S/C18H15ClN6OS2/c19-11-2-1-3-12(8-11)24-17(26)25-18-21-9-13(28-18)4-6-20-16-15-14(5-7-27-15)22-10-23-16/h1-3,5,7-10H,4,6H2,(H,20,22,23)(H2,21,24,25,26)
InChi Key: FAYAUAZLLLJJGH-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |