SNS-314 | 2446

A potent pan-Aurora kinase inhibitor. Inhibits Aurora kinases A, B, and C with IC₅₀ values of 9 nM, 31 nM and 3 nM, respectively. Displays potent anti-tumor activity.

SNS-314 is a potent pan-Aurora kinase inhibitor. Inhibits Aurora kinases A, B, and C with IC₅₀values of 9 nM, 31 nM and 3 nM, respectively.

2446 | SNS-314 DataSheet

Alternate Name/Synonyms: (3-chlorophenyl)-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea mesyalte

Appearance: Light yellow solid

Formulation: N/A

CAS Number: 1057249-41-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₅ClN₆OS₂

Molecular Weight: 430.93

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent pan-Aurora kinase inhibitor.

MDL Number: N/A

PubChem CID: 24995524

SMILES: C1=CC(=CC(=C1)Cl)NC(=O)NC2=NC=C(S2)CCNC3=NC=NC4=C3SC=C4

InChi: InChI=1S/C18H15ClN6OS2/c19-11-2-1-3-12(8-11)24-17(26)25-18-21-9-13(28-18)4-6-20-16-15-14(5-7-27-15)22-10-23-16/h1-3,5,7-10H,4,6H2,(H,20,22,23)(H2,21,24,25,26)

InChi Key: FAYAUAZLLLJJGH-UHFFFAOYSA-N