Solithromycin | B1222

Solithromycin (CEM-101) is a "fourth-generation" macrolide antibiotic, that has three binding sites and is acid stable. The three binding sites confer activity against bacteria resistant to the older macrolides and ketolides. Solithromycin displays excellent in vitro activity against a broad spectrum of Gram-positive respiratory tract pathogens, including macrolide-resistant strains.

Solithromycin (CEM-101) is a "fourth-generation" macrolide antibiotic, that has three binding sites and is acid stable. The three binding sites confer activity against bacteria resistant to the older macrolides and ketolides. Solithromycin displays excellent in vitro activity against a broad spectrum of Gram-positive respiratory tract pathogens, including macrolide-resistant strains.

B1222 | Solithromycin DataSheet

Alternate Name/Synonyms: (3aS,4R,7R,9R,10R,11R,13R,15S,15aR)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone; CEM101

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 760981-83-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄₃H₆₅FN₆O₁₀

Molecular Weight: 845.01

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A "fourth-generation" macrolide antibiotic

MDL Number: N/A

PubChem CID: 25242512

SMILES: CCC1C2(C(C(C(=O)C(CC(C(C(C(=O)C(C(=O)O1)(C)F)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=C(N=N4)C5=CC(=CC=C5)N)C

InChi: InChI=1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-14,18-20,22,45H2,1-11H3/t24-,25-,26+,27+,31+,32-,34-,35-,37-,38+,41-,42+,43-/m1/s1

InChi Key: IXXFZUPTQVDPPK-ZAWHAJPISA-N