SPHK1 Antibody| F40149-0.08ML/F40149-0.4ML/F50217-0.05ML/F50217-0.2ML/R33664-100UG

SPHK1 Antibody| F40149-0.08ML/F40149-0.4ML/F50217-0.05ML/F50217-0.2ML/R33664-100UG | Gentaur UK, US & Europe Distribution

Background: SPHK1 is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, FACS, IHC, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:50-1:100, Flow Cytometry: 1:10-1:50

Application Note: Titration of the SPHK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This SPHK1 antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 313-343 from the human protein was used as the immunogen for this SPHK1 antibody.

Storage: Aliquot the SPHK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A