Description
Potent inhibitor of yeast NAD⁺-dependent histone deacetylase Sir2p (IC₅₀ = 60 µM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.
Splitomycin is a potent inhibitor of yeast NAD⁺-dependent histone deacetylase Sir2p (IC₅₀ = 60 µM).
Alternate Name/Synonyms: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 5690-03-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₃H₁₀O₂
Molecular Weight: 198.2
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO (100 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A HDAC inhibitor
MDL Number: MFCD08705254
PubChem CID: 5269
SMILES: C1CC(=O)OC2=C1C3=CC=CC=C3C=C2
InChi: InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2
InChi Key: ISFPDBUKMJDAJH-UHFFFAOYSA-N
Additional Information
Storage Condition: |
+4°C |
Shipping Condition: |
RT |
Shelf Life: |
24months |