Splitomicin | 1610

Potent inhibitor of yeast NAD⁺-dependent histone deacetylase Sir2p (IC₅₀ = 60 µM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.

Splitomycin is a potent inhibitor of yeast NAD⁺-dependent histone deacetylase Sir2p (IC₅₀ = 60 µM).

1610 | Splitomicin DataSheet

Alternate Name/Synonyms: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 5690-03-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₀O₂

Molecular Weight: 198.2

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (100 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A HDAC inhibitor

MDL Number: MFCD08705254

PubChem CID: 5269

SMILES: C1CC(=O)OC2=C1C3=CC=CC=C3C=C2

InChi: InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2

InChi Key: ISFPDBUKMJDAJH-UHFFFAOYSA-N